Email spoofing attacks pose a severe threat to email systems by forging the sender’s address to deceive email recipients. Sender Policy Framework (SPF), an email authentication protocol that verifies senders by their IP addresses, is critical for preventing email spoofing attacks. However, attackers can bypass SPF validation and launch convincing spoofing attacks that evade email authentication. This paper proposes BreakSPF, a novel attack framework that bypasses SPF validation to enable email spoofing. Attackers can actively target domains with permissive SPF configurations by utilizing cloud services, proxies, and content delivery networks (CDNs) with shared IP pools. We leverage BreakSPF to conduct a large-scale experiment evaluating the security of SPF deployment across Tranco top 1 million domain names. We uncover that 23,916 domains are vulnerable to BreakSPF attacks, including 23 domains that rank within the top 1,000 most popular domains. The results underscore the widespread SPF configuration vulnerabilities and their potential to undermine the security of email systems. Our study provides valuable insights for detecting and mitigating SPF vulnerabilities and strengthening email system security overall.